DESeq2 Differential Expression Skill Purpose Provide DESeq2 differential expression analysis with normalization, statistical modeling, and visualization. Capabilities - Size factor normalization - Negative binomial modeling - Shrinkage estimation - Batch effect modeling - Multi-factor designs - Result visualization (MA plots, volcano plots) Usage Guidelines - Design experiments with appropriate replication - Include batch effects in model when present - Apply appropriate shrinkage estimators - Use multiple testing correction - Generate publication-quality visualizations - Document analysis pa…