Overview The skill performs rigorous quality control on a COBRApy before it enters any flux analysis pipeline. An invalid model silently produces biologically meaningless fluxes; validation catches structural errors early. Validation covers six categories: (1) mass/charge balance, (2) feasibility and biomass production, (3) dead-end metabolites, (4) stoichiometric consistency, (5) thermodynamic loop detection, and (6) GPR rule integrity. --- Workflow Step 1 — Load the Model Step 2 — Mass and Charge Balance Check Unbalanced reactions are among the most common modelling errors. COBRApy computes…