PubChem Database Overview PubChem is the world's largest freely available chemical database with 110M+ compounds and 270M+ bioactivities. Query chemical structures by name, CID, or SMILES, retrieve molecular properties, perform similarity and substructure searches, access bioactivity data using PUG-REST API and PubChemPy. When to Use This Skill This skill should be used when: - Searching for chemical compounds by name, structure (SMILES/InChI), or molecular formula - Retrieving molecular properties (MW, LogP, TPSA, hydrogen bonding descriptors) - Performing similarity searches to find structu…