TileDB-VCF When to use Use for cohort variant storage, incremental sample ingestion, interval queries, and exporting subsets for downstream genomics. TileDB-VCF stores records; it does not perform joint variant calling, association testing, normalization, or population structure adjustment. Dataset size alone does not determine whether cloud execution is appropriate: benchmark the intended sample, region, and attribute workload. This skill targets released TileDB-VCF 0.40.3 . Native Python/CLI checks used two synthetic single-sample VCFs on macOS ARM64. Cloud client 0.14.4 contracts were chec…