TMB-MSI Calculator Skill Purpose Calculate tumor mutation burden and microsatellite instability for immunotherapy biomarker assessment. Capabilities - TMB calculation from VCF - MSI status determination - Neoantigen prediction - HLA typing integration - Biomarker thresholds - Clinical report generation Usage Guidelines - Calculate TMB with appropriate normalization - Determine MSI status accurately - Predict neoantigens for immunotherapy - Apply clinical thresholds for reporting - Generate actionable reports - Document methodology and thresholds Dependencies - TMBcat - MSIsensor2 - MANTIS Pro…