Aging & Cellular Senescence Research Aging Research Reasoning Before querying any tool, ask the central question: is this a cause or consequence of aging? Senescence markers (SA-β-gal, p16/CDKN2A, SASP factors like IL-6 and IL-8) indicate that senescent cells are present. But their presence does not prove that senescence is driving the phenotype. Correlation is easy to establish. Causation requires an intervention. If senolytic drugs (dasatinib+quercetin, fisetin, navitoclax) clear senescent cells and the age-related phenotype improves, that is causal evidence. If clearing senescent cells has…