Drug Mechanism of Action Investigation Investigation Philosophy Drug mechanism research follows one core question chain: Target - Downstream Effect - Pathway - Organ Effect - Clinical Outcome Start with the drug's primary target. What receptor, enzyme, or transporter does it bind? Then trace forward: what does inhibiting/activating that target do immediately? What pathway is disrupted? What organ-level change results? What does the patient experience? The LLM already knows drug pharmacology. This skill teaches HOW TO INVESTIGATE using available tools, not what mechanisms exist. When to Use -…