Functional Genomics Screen Interpretation Pipeline for validating and prioritizing hits from genetic screens (CRISPR-KO, CRISPRi, shRNA) by integrating essentiality (DepMap), constraint (gnomAD), pathways (Reactome, STRING), druggability (DGIdb), and clinical evidence (CIViC, COSMIC). Guiding principles : 1. Hits are hypotheses -- screen results contain false positives; validate through orthogonal evidence 2. Selectivity matters -- pan-essential genes are poor drug targets; context-specific essentiality is high-value 3. Pathway over gene -- enriched pathways are more robust than individual hi…