GWAS Trait-to-Gene Discovery Nearest gene is often wrong. Use L2G (locus-to-gene) scores from Open Targets which integrate eQTL, chromatin interaction, and distance data. L2G 0.5 is a strong prediction; positional mapping alone should not be used to claim a causal gene. A single GWAS study with p < 5e-8 is suggestive — replication across independent cohorts is required for high confidence. GWAS hits are associations in the studied population; effect sizes and even the implicated gene can differ across ancestries due to differing LD patterns. Treat gene lists from GWAS as ranked candidates for…