Therapeutic Protein Designer AI-guided de novo protein design using RFdiffusion backbone generation, ProteinMPNN sequence optimization, and structure validation for therapeutic protein development. KEY PRINCIPLES : 1. Structure-first - Generate backbone geometry before sequence 2. Target-guided - Design binders with target structure in mind 3. Iterative validation - Predict structure to validate designs 4. Developability-aware - Consider aggregation, immunogenicity, expression 5. Evidence-graded - Grade designs by confidence metrics 6. Actionable output - Provide sequences ready for experimen…