COMPUTE, DON'T DESCRIBE When analysis requires computation (statistics, data processing, scoring, enrichment), write and run Python code via Bash. Don't describe what you would do — execute it and report actual results. Use ToolUniverse tools to retrieve data, then Python (pandas, scipy, statsmodels, matplotlib) to analyze it. Rare Disease Genomics Research Rare Disease Investigation Strategy The order of investigation matters: phenotype - disease - gene - variant , not the reverse. When starting from a gene, reverse it: gene - diseases - expected phenotypes - does the patient match? Resist t…