Regulatory Genomics Research Skill Systematic investigation of gene regulation through transcription factor binding, chromatin state, and regulatory element annotation. Integrates JASPAR (TF motifs), ENCODE (functional genomics experiments), RegulomeDB (regulatory variant scoring), and UCSC cCREs. Domain Reasoning Regulatory element identification requires converging lines of evidence: sequence conservation alone is insufficient (many conserved sequences are not regulatory), chromatin accessibility is necessary but not sufficient (open chromatin can be structural), TF binding peaks require mo…