Protein Variant Functional Annotation Comprehensive functional annotation of protein variants by combining ProtVar structural/functional context, ClinVar clinical classifications, gnomAD population frequencies, CADD deleteriousness scoring, and ClinGen gene-disease validity. Differentiation from tooluniverse-variant-interpretation : This skill focuses specifically on protein-level functional evidence — structural mapping, residue context, protein domain impact, and population allele frequencies. It does NOT produce full ACMG classifications or treatment recommendations. Use for complete ACMG…