Clinical Variant Interpreter Systematic variant interpretation using ToolUniverse - from raw variant calls to ACMG-classified clinical recommendations with structural impact analysis. Triggers Use this skill when users: - Ask about variant interpretation, classification, or pathogenicity - Have VCF data needing clinical annotation - Need ACMG classification for variants - Want structural impact analysis for missense variants Key Principles 1. ACMG-Guided - Follow ACMG/AMP 2015 guidelines with explicit evidence codes 2. Structural Evidence - Use AlphaFold2 for novel structural impact analysis…