VEP Variant Annotator Skill Purpose Provide comprehensive variant annotation using Variant Effect Predictor with clinical database integration. Capabilities - Functional consequence prediction - Population frequency annotation (gnomAD) - Clinical database integration (ClinVar, COSMIC) - Custom annotation plugins - Pathogenicity score integration (CADD, REVEL) - Regulatory region annotation Usage Guidelines - Configure VEP with relevant annotation sources - Include population frequency databases - Add clinical databases for interpretation - Use pathogenicity predictors for prioritization - Doc…